Blood Flow Regulates Glomerular Capillary Formation in Zebrafish Pronephros.

ABSTRACT:

Background

The renal glomerulus is a tuft of capillaries in Bowman's capsule and functions as a blood-filtration unit in the kidney. The unique glomerular capillary tuft structure is relatively conserved through vertebrate species. However, the morphogenetic mechanism governing glomerular capillary tuft formation remains elusive.

Methods

To clarify how glomerular capillaries develop, we analyzed glomerular capillary formation in the zebrafish pronephros by exploiting fluorescence-based bio-imaging technology.

Results

During glomerular capillary formation in the zebrafish pronephros, endothelial cells initially sprouted from the dorsal aorta and formed the capillaries surrounding the bilateral glomerular primordia in response to podocyte progenitor-derived vascular end

SUBMITTER: Nishimura Y 

PROVIDER: S-EPMC9136892 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature