Hyperkalemia and Metabolic Acidosis Occur at a Higher eGFR in Sickle Cell Disease.

ABSTRACT:

Background

People with sickle cell disease (SCD) have an elevated estimated glomerular filtration rate (eGFR) compared with the general population, and this may alter the usual creatinine-based eGFR cutoffs for which physiologic evidence of kidney dysfunction is apparent. This study aimed to identify eGFR thresholds for hyperkalemia and metabolic acidosis in patients with SCD.

Methods

This was a cross-sectional analysis of 733 patients with severe (hemoglobin SS or Sβ ⁰-thalassemia) SCD genotype, 238 patients with moderate (hemoglobin SC or Sβ ⁺-thalassemia) SCD genotype, and 1333 age- and sex-matched African Americans from the National Health and Nutrition Examination Survey (NHANES). The prevalence rates of hyperkalemia and metabolic aci

SUBMITTER: Saraf SL 

PROVIDER: S-EPMC9136900 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature