Systemic Profile of Cytokines in Arteriovenous Fistula Patients and Their Associations with Maturation Failure.

ABSTRACT:

Background

Systemic cytokines are elevated in patients with chronic kidney disease (CKD) and on hemodialysis compared with the general population. However, whether cytokine levels interfere with vascular remodeling, increasing the risk of arteriovenous fistula (AVF) failure, remains unknown.

Methods

This is a case-control study of 64 patients who underwent surgery for AVF creation (32 with AVF maturation failure and 32 matching controls with successful maturation). A total of 74 cytokines, including chemokines, interferons, interleukins, and growth factors, were measured in preoperative plasma samples using multiplex assays. Sixty-two patients were included in the statistical analyses. Associations with AVF failure were assessed using paired comparisons and conditional logis

SUBMITTER: Martinez L 

PROVIDER: S-EPMC9136910 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature