Longitudinal Associations between Low Serum Bicarbonate and Linear Growth in Children with CKD.

ABSTRACT:

Background

Poor linear growth is a consequence of chronic kidney disease (CKD) that has been linked to adverse outcomes. Metabolic acidosis (MA) has been identified as a risk factor for growth failure. We investigated the longitudinal relationship between MA and linear growth in children with CKD and examined whether treatment of MA modified linear growth.

Methods

To describe longitudinal associations between MA and linear growth, we used serum bicarbonate levels, height measurements, and standard deviation (z scores) of children enrolled in the prospective cohort study Chronic Kidney Disease in Children. Analyses were adjusted for covariates recognized as correlating with poor growth, including demographic characteristics, glomerular filtration rate (GFR), proteinuria, calc

SUBMITTER: Brown DD 

PROVIDER: S-EPMC9136912 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature