Isolation and characterization of five novel disulfide-poor conopeptides from Conus marmoreus venom.

ABSTRACT:

Background

Conopeptides from cone snail venom have aroused great interest related to the discovery of novel bioactive candidates, due to their excellent prospects for the treatment of various health problems such as pain, addiction, psychosis and epilepsy. In order to explore novel biopeptides, we investigated the structure and function of five novel conopeptides isolated from the venom of Conus marmoreus from South China Sea.

Methods

C. marmoreus crude venom was prepared, fractionated and purified by HPLC system. The primary sequences of the five novel disulfide-poor conopeptides Mr-1 to Mr-5 were identified by comprehensive analysis of de novo MALDI-TOF tandem mass spectrometry and Edman degradation data. In order to investigate their function, these f

SUBMITTER: Fu Y 

PROVIDER: S-EPMC9136937 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature