Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis.

ABSTRACT:

Background

The microbial population of the intestinal tract and its relationship to specific diseases has been extensively studied during the past decade. However, reports characterizing the bile microbiota are rare. This study aims to investigate the microbiota composition in patients with pancreaticobiliary cancers and benign diseases by 16S rRNA gene amplicon sequencing and to evaluate its potential value as a biomarker for the cancer of the bile duct, pancreas, and gallbladder.

Results

We enrolled patients who were diagnosed with cancer, cystic lesions, and inflammation of the pancreaticobiliary tract. The study cohort comprised 244 patients. We extracted microbiome-derived DNA from the bile juice in surgically resected gallbladders. The microbiome composition was not si

SUBMITTER: Kirishima M 

PROVIDER: S-EPMC9137208 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature