Engineering of Tracheal Grafts Based on Recellularization of Laser-Engraved Human Airway Cartilage Substrates.

ABSTRACT:

Objective

Implantation of tissue-engineered tracheal grafts represents a visionary strategy for the reconstruction of tracheal wall defects after resections and may develop into a last chance for a number of patients with severe cicatricial stenosis. The use of a decellularized tracheal substrate would offer an ideally stiff graft, but the matrix density would challenge efficient remodeling into a living cartilage. In this study, we hypothesized that the pores of decellularized laser-perforated tracheal cartilage (LPTC) tissues can be colonized by adult nasal chondrocytes (NCs) to produce new cartilage tissue suitable for the repair of tracheal defects.

Design

Human, native tracheal specimens, isolated from cadaveric donors, were exposed to decellularized and laser engraving

SUBMITTER: Baranovskii D 

PROVIDER: S-EPMC9137320 | biostudies-literature | 2022 Jan-Mar

REPOSITORIES: biostudies-literature