Electron Transfer to the Trinuclear Copper Cluster in Electrocatalysis by the Multicopper Oxidases.

ABSTRACT: High-potential multicopper oxidases (MCOs) are excellent catalysts able to perform the oxygen reduction reaction (ORR) at remarkably low overpotentials. Moreover, MCOs are able to interact directly with the electrode surfaces via direct electron transfer (DET), that makes them the most commonly used electrocatalysts for oxygen reduction in biofuel cells. The central question in MCO electrocatalysis is whether the type 1 (T1) Cu is the primary electron acceptor site from the electrode, or whether electrons can be transferred directly to the trinuclear copper cluster (TNC), bypassing the rate-limiting intramolecular electron transfer step from the T1 site. Here, using site-directed mutagenesis and electrochemical methods combined with data modeling of electrode kinetics, we have found that t

SUBMITTER: Sekretareva A 

PROVIDER: S-EPMC9137402 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature