Structural differences in the hippocampus and amygdala of behaviorally inhibited macaque monkeys.

ABSTRACT: Behavioral inhibition is a temperamental disposition to react warily when confronted by unfamiliar people, objects, or events. Behaviorally inhibited children are at greater risk of developing anxiety disorders later in life. Previous studies reported that individuals with a history of childhood behavioral inhibition exhibit abnormal activity in the hippocampus and amygdala. However, few studies have investigated the structural differences that may underlie these functional abnormalities. In this exploratory study, we evaluated rhesus monkeys exhibiting a phenotype consistent with human behavioral inhibition. We performed quantitative neuroanatomical analyses that cannot be performed in humans including estimates of the volume and neuron number of distinct hippocampal regions and amygdala

SUBMITTER: Villard J 

PROVIDER: S-EPMC9137438 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature