Stability of enveloped and nonenveloped viruses in hydrolyzed gelatin liquid formulation.

ABSTRACT:

Background

The thermal stability of viruses in gelatin liquid formulations for medical research and application is poorly understood and this study aimed to examine the thermal stability of 4 enveloped and nonenveloped DNA and RNA viruses in hydrolyzed gelatin liquid formulations.

Methods

Bovine herpesvirus (BHV) was used as a model virus to examine the molecular weight (MW), concentration and gelatin type and to optimize virus stability in liquid formulations at 25 °C and 4 °C. Using the model virus liquid formulation, the stability of multiple enveloped and nonenveloped RNA and DNA viruses, including parainfluenza virus, reovirus (RV), BHV, and adenovirus (AdV), was monitored over up to a 30-week storage period.

Results

The BHV model virus was considered stable afte

SUBMITTER: Kadji FMN 

PROVIDER: S-EPMC9137439 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature