SspH, a Novel HATPase Family Regulator, Controls Antibiotic Biosynthesis in Streptomyces.

ABSTRACT: Streptomyces can produce a wealth of pharmaceutically valuable antibiotics and other bioactive compounds. Production of most antibiotics is generally low due to the rigorously controlled regulatory networks, in which global/pleiotropic and cluster-situated regulatory proteins coordinate with various intra- and extracellular signals. Thus, mining new antibiotic regulatory proteins, particularly the ones that are widespread, is essential for understanding the regulation of antibiotic biosynthesis. Here, in the biopesticide milbemycin producing strain Streptomyces bingchenggensis, a novel global/pleiotropic regulatory protein, SspH, a single domain protein containing only the HATPase domain, was identified as being involved in controlling antibiotic biosynthesis. The sspH

SUBMITTER: Yang X 

PROVIDER: S-EPMC9137472 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature