Pectolinarin Inhibits the Bacterial Biofilm Formation and Thereby Reduces Bacterial Pathogenicity.

ABSTRACT: Bacterial biofilms are a growing problem as it is a major cause of nosocomial infection from urinary catheters to chronic tissue infections and provide resistance to a variety of antibiotics and the host's immune system. The effect of pectolinarin on the biofilm formation in Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Streptococcus mutans, Streptococcus sobrinus, Staphylococcus aureus, Pseudomonas aeruginosa, Cutibacterium acnes, and Porphyromonas gingivalis was studied in TSBg (tryptic soy broth supplemented with 1% glucose). Pectolinarin inhibited biofilm formation of E. faecalis (IC₅₀ = 0.39 μg/mL), E. faecium (IC₅₀ = 0.19 μg/mL), E. coli (IC₅₀ = 0.25 μ

SUBMITTER: Kim D 

PROVIDER: S-EPMC9137516 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature