Identification of a Novel Inhibitor of TfR1 from Designed and Synthesized Muriceidine A Derivatives.

ABSTRACT: The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. TfR1 is often reported to be overexpressed in malignant cells, and this increase may be associated with poor prognosis in different types of cancer, which makes it an attractive target for antitumor therapy. The marine natural product Muriceidine A is a potent anticancer agent reported in our previous work. In this study, we designed and synthesized a series of Muriceidine A derivatives and described the systematic investigation into their cytotoxic activities against four tumor cells. Most of the derivatives showed stronger antitumor activity and we found that the introduction of electron-donating groups at position C-2 of unsaturated piperidine was beneficial to anticanc

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9137542 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature