Dataset Information

Comparative Analysis of Human and Animal E. coli: Serotyping, Antimicrobial Resistance, and Virulence Gene Profiling.

ABSTRACT: Widespread multidrug-resistant (MDR) and multi-virulent diarrheagenic E. coli create several crises among human and animal populations worldwide. For this reason, we looked forward to a breakthrough with this issue and tried to highlight these emerging threats. A total of 140 diarrheagenic E. coli isolates were recovered from animal and human sources. The O26 serotype, alongside the ampicillin/cefoxitin resistance phenotype, was predominant among both human and animal isolates. Of note, imipenem represented the most effective antibiotic against all the investigated isolates. Unfortunately, 90% and 57.9% of the tested isolates showed MDR and multi-virulent patterns, respectively. The animal isolates were more virulent and showed higher sensitivity to antimicrobial agents. Both animal and human isolates could not be arranged into related clusters. A strong negative correlation between the existence of virulence genes and antimicrobial resistance was clearly detected. A significant correlation between serotypes and antimicrobial resistance was not detected; meanwhile, a significant positive correlation between some serotypes and the presence of certain virulence genes was announced. Finally, our results confirmed the urgent need for restricted guidelines, in addition to new alternative therapies, due to the genetic diversity and wide spreading of MDR side by side with multi-virulent E. coli isolates.

SUBMITTER: Bendary MM

PROVIDER: S-EPMC9137549 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Comparative Analysis of Human and Animal E. coli: Serotyping, Antimicrobial Resistance, and Virulence Gene Profiling

Bendary Mahmoud M MM Abdel-Hamid Marwa I MI Alshareef Walaa A WA Alshareef Hanan M HM Mosbah Rasha A RA Omar Nasreen N NN Al-Sanea Mohammad M MM Alhomrani Majid M Alamri Abdulhakeem S AS Moustafa Walaa H WH

Antibiotics (Basel, Switzerland) 20220421 5

Widespread multidrug-resistant (MDR) and multi-virulent diarrheagenic <i>E. coli</i> create several crises among human and animal populations worldwide. For this reason, we looked forward to a breakthrough with this issue and tried to highlight these emerging threats. A total of 140 diarrheagenic <i>E. coli</i> isolates were recovered from animal and human sources. The O26 serotype, alongside the ampicillin/cefoxitin resistance phenotype, was predominant among both human and animal isolates. Of ...[more]

PMID: 35625196

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Dataset Information

Comparative Analysis of Human and Animal E. coli: Serotyping, Antimicrobial Resistance, and Virulence Gene Profiling.

Publications

Comparative Analysis of Human and Animal E. coli: Serotyping, Antimicrobial Resistance, and Virulence Gene Profiling

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Dataset Information

Comparative Analysis of Human and Animal E.&nbsp;coli: Serotyping, Antimicrobial Resistance, and Virulence Gene Profiling.

Publications

Comparative Analysis of Human and Animal E. coli: Serotyping, Antimicrobial Resistance, and Virulence Gene Profiling

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Comparative Analysis of Human and Animal E. coli: Serotyping, Antimicrobial Resistance, and Virulence Gene Profiling.