Human-Origin iPSC-Based Recellularization of Decellularized Whole Rat Livers.

ABSTRACT: End-stage liver diseases lead to mortality of millions of patients, as the only treatment available is liver transplantation and donor scarcity means that patients have to wait long periods before receiving a new liver. In order to minimize donor organ scarcity, a promising bioengineering approach is to decellularize livers that do not qualify for transplantation. Through decellularization, these organs can be used as scaffolds for developing new functional organs. In this process, the original cells of the organ are removed and ideally should be replaced by patient-specific cells to eliminate the risk of immune rejection. Induced pluripotent stem cells (iPSCs) are ideal candidates for developing patient-specific organs, yet the maturity and functionality of iPSC-derived cells do not match

SUBMITTER: Acun A 

PROVIDER: S-EPMC9137624 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature