The Vascular Niche for Adult Cardiac Progenitor Cells.

ABSTRACT: Research on cardiac progenitor cell populations has generated expectations about their potential for cardiac regeneration capacity after acute myocardial infarction and during physiological aging; however, the endogenous capacity of the adult mammalian heart is limited. The modest efficacy of exogenous cell-based treatments can guide the development of new approaches that, alone or in combination, can be applied to boost clinical efficacy. The identification and manipulation of the adult stem cell environment, termed niche, will be critical for providing new evidence on adult stem cell populations and improving stem-cell-based therapies. Here, we review and discuss the state of our understanding of the interaction of adult cardiac progenitor cells with other cardiac cell populations, with

SUBMITTER: Herrero D 

PROVIDER: S-EPMC9137669 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature