Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production in Streptomyces spp.

ABSTRACT: Streptomyces bacteria produce a wide number of antibiotics and antitumor compounds that have attracted the attention of pharmaceutical and biotech companies. In this study, we provide evidence showing that the xylem sap from grapevines has a positive effect on the production of different antibiotics by several Streptomyces species, including S. ambofaciens ATCC 23877 and S. argillaceus ATCC 12596 among others. The production of several already known compounds was induced: actinomycin D, chromomycin A3, fungichromin B, mithramycin A, etc., and four compounds with molecular formulas not included in the Dictionary of Natural Products (DNP v28.2) were also produced. The molecules present in the xylem sap that acts as elicitors were smaller than 3 kDa and soluble in

SUBMITTER: Santamaria RI 

PROVIDER: S-EPMC9137808 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature