Bioactive Phytochemicals of Citrus reticulata Seeds-An Example of Waste Product Rich in Healthy Skin Promoting Agents.

ABSTRACT: Phytochemical investigation of Egyptian mandarin orange (Citrus reticulata Blanco, F. Rutaceae) seeds afforded thirteen known compounds, 1-13. The structures of isolated compounds were assigned using 1D and 2D NMR and HRESIMS analyses. To characterize the pharmacological activity of these compounds, several integrated virtual screening-based and molecular dynamics simulation-based experiments were applied. As a result, compounds 2, 3 and 5 were putatively identified as hyaluronidase, xanthine oxidase and tyrosinase inhibitors. The subsequent in vitro testing was done to validate the in silico-based experiments to highlight the potential of these flavonoids as promising hyaluronidase, xanthine oxidase and tyrosinase inhibitors with IC₅₀ v

SUBMITTER: Al-Warhi T 

PROVIDER: S-EPMC9138151 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature