Seizure Susceptibility and Sleep Disturbance as Biomarkers of Epileptogenesis after Experimental TBI.

ABSTRACT:

Objectives

We investigated whether seizure susceptibility increases over weeks-months after experimental traumatic brain injury (TBI), and whether seizure susceptibility in rats predicts the development of post-traumatic epilepsy (PTE) or epileptiform activity. We further investigated whether rats develop chronic sleep disturbance after TBI, and whether sleep disturbance parameters-alone or in combination with pentylenetetrazol (PTZ) test parameters-could serve as novel biomarkers for the development of post-traumatic epileptogenesis.

Methods

TBI was induced in adult male Sprague-Dawley rats with lateral fluid-percussion injury. Sham-operated experimental controls underwent craniectomy without exposure to an impact force. Seizure susceptibility was tested with a PTZ test (30

SUBMITTER: Andrade P 

PROVIDER: S-EPMC9138230 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature