Characterization of Mast Cells from Healthy and Varicose Human Saphenous Vein.

ABSTRACT: Mast cells (MCs) are distributed in tissues throughout the body and are highly involved in many physiological and pathophysiological processes. The potential and involvement of different MC phenotypes are still not well understood. MCs are present in blood vessel walls, but their specific phenotypic features are unknown. We aimed at characterizing MCs from human saphenous veins for localization, mediator content, and receptor expression. This was done in MCs from both healthy and varicose human saphenous veins (hSV and vSV, respectively). For both vSV and hSV, we found that vein MCs are mainly present in the tunica adventitia (99% MCs in adventitia) and that the population consists of both MC_T and MC_TC phenotypes (vSV: 55% MC_T, hSV: 64% MC_T). The

SUBMITTER: Callesen KT 

PROVIDER: S-EPMC9138295 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature