G-Quadruplex-Binding Proteins: Promising Targets for Drug Design.

ABSTRACT: G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with the potential to form G4s are abundant in regulatory regions of the genome including telomeres, promoters and 5' non-coding regions, indicating they fulfill important genome regulatory functions. Generally, G4s perform various biological functions by interacting with proteins. In recent years, an increasing number of G-quadruplex-binding proteins have been identified with biochemical experiments. G4-binding proteins are involved in vital cellular processes such as telomere maintenance, DNA replication, gene transcription, mRNA processing. Therefore, G4-binding proteins are also associated with various human diseases. An intensive study of G4-protein interactions provides an attractive approach for pote

SUBMITTER: Shu H 

PROVIDER: S-EPMC9138358 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature