Remodeling of the Dermal Extracellular Matrix in a Tissue-Engineered Psoriatic Skin Model by n-3 Polyunsaturated Fatty Acids.

ABSTRACT: Psoriasis is an inflammatory skin disease mainly associated with an epidermal disorder. However, the involvement of the dermal extracellular matrix (ECM) composition in psoriasis is still poorly understood. This study aimed to investigate the expression of ECM components in psoriatic skin substitutes (PS^-) compared with healthy skin substitutes (HS^-), as well as the effect of an n-3 polyunsaturated fatty acid, namely α-linolenic acid (ALA), on the psoriatic dermal compartment (PS^ALA+). Liquid chromatography tandem mass spectrometry analyses revealed that the lipidome of PS^- contained higher amounts of n-6 derived prostaglandins (PGE₂) and lipoxygenase products (9-HODE and 15-HETE). ALA supplementation increased the levels of PGE_3<

SUBMITTER: Simard M 

PROVIDER: S-EPMC9138383 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature