Lipid Metabolic Alterations in the ALS-FTD Spectrum of Disorders.

ABSTRACT: There is an increasing interest in the study of the relation between alterations in systemic lipid metabolism and neurodegenerative disorders, in particular in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). In ALS these alterations are well described and evident not only with the progression of the disease but also years before diagnosis. Still, there are some discrepancies in findings relating to the causal nature of lipid metabolic alterations, partly due to the great clinical heterogeneity in ALS. ALS presentation is within a disorder spectrum with Frontotemporal Dementia (FTD), and many patients present mixed forms of ALS and FTD, thus increasing the variability. Lipid metabolic and other systemic metabolic alterations have not been well studied in FTD, or in AL

SUBMITTER: Godoy-Corchuelo JM 

PROVIDER: S-EPMC9138405 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature