Total Tumor Volume on ¹⁸F-PSMA-1007 PET as Additional Imaging Biomarker in mCRPC Patients Undergoing PSMA-Targeted Alpha Therapy with ²²⁵Ac-PSMA-I&T.

ABSTRACT:

Background

PSMA-based alpha therapy using ²²⁵Ac-PSMA-I&T provides treatment for metastatic castration-resistant prostate cancer (mCRPC), even after the failure of ¹⁷⁷Lu-PSMA radioligand therapy (RLT). In clinical routine, the total tumor volume (TTV) on PSMA PET impacts therapy outcomes and plays an increasing role in mCRPC patients. Hence, we aimed to assess TTV and its changes during ²²⁵Ac-PSMA-I&T RLT.

Methods

mCRPC patients undergoing RLT with ²²⁵Ac-PSMA-I&T with available ¹⁸F-PSMA-1007 PET/CT prior to therapy initiation were included. TTV was assessed in all patients using established cut-off values. Image derived, clinical and biochemistry parameters (PSA, LDH, AP, pain score) were analyzed prior to and after two c

SUBMITTER: Unterrainer LM 

PROVIDER: S-EPMC9138410 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature