Tolerance of Rodents to an Intravenous Bolus Injection of Sodium Nitrate in a High Concentration.

ABSTRACT: Nitrate, the inorganic anion NO₃^-, is found in many foods and is an endogenous mammalian metabolite, which is supplied mostly through the diet. Although much is known about the safety of sodium nitrate when given per os, methodological safety data on intravenous bolus injection of sodium nitrate to rodents are lacking. Recently, we have proposed a new use for nitrate, as a contrast agent for magnetic resonance imaging that will be metal free and leave no traces in the body and the environment further to the imaging examination. It was shown that a stable isotope-labelled analog of this ion (¹⁵NO₃^-), in a sodium nitrate solution form and hyperpolarized state, produces a high magnetic resonance signal with prolonged visibility. Th

SUBMITTER: Katz-Brull R 

PROVIDER: S-EPMC9138515 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature