Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue.

ABSTRACT: Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system. Accurate identification of microglia and their reactivity state is therefore essential to further our understanding of CNS pathophysiology. Many staining techniques have been used to visualise microglia in rodent and human tissue, and immunostaining is currently the most frequently used. Historically, identification of microglia was predominantly based on morphological structure, however, recently there has been a reliance on selective antigen expression, and microglia-specific markers have been identified providing increased certainty that the cells

SUBMITTER: Uff CEG 

PROVIDER: S-EPMC9138569 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature