Characterization of the Upper Respiratory Bacterial Microbiome in Critically Ill COVID-19 Patients.

ABSTRACT: The upper respiratory tract (URT) microbiome can contribute to the acquisition and severity of respiratory viral infections. The described associations between URT microbiota and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited at microbiota genus level and by the lack of functional interpretation. Our study, therefore, characterized the URT bacterial microbiome at species level and their encoded pathways in patients with COVID-19 and correlated these to clinical outcomes. Whole metagenome sequencing was performed on nasopharyngeal samples from hospitalized patients with critical COVID-19 (n = 37) and SARS-CoV-2-negative individuals (n = 20). Decreased bacterial diversity, a reduction in commensal bacteria, and high abundance of pathogenic ba

SUBMITTER: Bai X 

PROVIDER: S-EPMC9138573 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature