Cerebellum-Cortical Interaction in Spatial Navigation and Its Alteration in Dementias.

ABSTRACT: The cerebellum has a homogeneous structure and performs different computational functions such as modulation/coordination of the communication between cerebral regions, and regulation/integration of sensory information. Albeit cerebellar activity is generally associated with motor functions, several recent studies link it to various cognitive functions, including spatial navigation. In addition, cerebellar activity plays a modulatory role in different cognitive domains and brain processes. Depending on the network involved, cerebellar damage results in specific functional alterations, even when no function loss might be detected. In the present review, we discuss evidence of brainstem degeneration and of a substantial reduction of neurons in nuclei connected to the inferior olivary nucleus

SUBMITTER: Mirino P 

PROVIDER: S-EPMC9138670 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature