Distinct immune profiles of HIV-infected subjects are linked to specific lipid mediator signature.

ABSTRACT:

Introduction

To date, with no prophylactic human immunodeficiency virus (HIV) vaccine available, HIV incidence rates remain undefeated. Despite full virological suppression, HIV+ individuals exhibit a higher rate of cardiovascular disorders and cancers what is attributed to the residual, persistent levels of immune activation.

Methods

We have established the Virological and Immunological Monitoring (VIM) platform and forty VIM samples that included treated immunological responders (IRs) or nonresponders (INRs), viremic untreated subjects and uninfected controls, were phenotyped by flow cytometry and plasma was used to quantify proinflammatory eicosanoids and the specialized proresolving mediators by liquid chromatography tandem mass spectrometry.

Results

While HIV inf

SUBMITTER: Sips M 

PROVIDER: S-EPMC9138705 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature