Environmentally Acquired Bacillus and Their Role in C. difficile Colonization Resistance.

ABSTRACT: Clostridioides difficile is an environmentally acquired, anaerobic, spore-forming bacterium which ordinarily causes disease following antibiotic-mediated dysbiosis of the intestinal microbiota. Although much is understood regarding the life cycle of C. difficile, the fate of C. difficile spores upon ingestion remains unclear, and the underlying factors that predispose an individual to colonization and subsequent development of C. difficile infection (CDI) are not fully understood. Here, we show that Bacillus, a ubiquitous and environmentally acquired, spore-forming bacterium is associated with colonization resistance to C. difficile. Using animal models, we first provide evidence that animals housed under conditions that mimic reduced environmental

SUBMITTER: Ferreira WT 

PROVIDER: S-EPMC9138776 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature