Concurrent urinary organophosphate metabolites and acetylcholinesterase activity in Ecuadorian adolescents.

ABSTRACT:

Background

Organophosphates are insecticides that inhibit the enzymatic activity of acetylcholinesterase (AChE). Because of this, AChE is considered a physiological marker of organophosphate exposure in agricultural settings. However, limited research exists on the associations between urinary organophosphate metabolites and AChE activity in children.

Methods

This study included 526 participants from 2 exams (April and July-October 2016) of ages 12-17 years living in agricultural communities in Ecuador. AChE activity was measured at both examinations, and organophosphate metabolites, including para-nitrophenol (PNP), 3,5,6-trichloro-2-pyridinol (TCPy), and malathion dicarboxylic acid (MDA) were measured in urine collected in July-October. We used generalized estimating equat

SUBMITTER: Skomal AE 

PROVIDER: S-EPMC9138777 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature