Sex Plays a Multifaceted Role in Asthma Pathogenesis.

ABSTRACT: Sex is considered an important risk factor for asthma onset and exacerbation. The prevalence of asthma is higher in boys than in girls during childhood, which shows a reverse trend after puberty-it becomes higher in adult females than in adult males. In addition, asthma severity, characterized by the rate of hospitalization and relapse after discharge from the emergency department, is higher in female patients. Basic research indicates that female sex hormones enhance type 2 adaptive immune responses, and male sex hormones negatively regulate type 2 innate immune responses. However, whether hormone replacement therapy in postmenopausal women increases the risk of current asthma and asthma onset remains controversial in clinical settings. Recently, sex has also been shown to influence the p

SUBMITTER: Miyasaka T 

PROVIDER: S-EPMC9138801 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature