Towards Understanding the Lymph Node Response to Skin Infection with Saprophytic Staphylococcus epidermidis.

ABSTRACT: In individuals with lymphedema, diabetic foot, or other diseases, infections with saprophytes are common. The response of major cell subpopulations in the draining lymph nodes to skin infection with Staphylococcus epidermidis was assessed using the rat model. After massive subepidermal infection, a cytometric evaluation showed an increase in cytotoxic and helper T lymphocytes and major subpopulations of the innate immune response. Three weeks later, signs of inflammation reduction with an increase in the content of memory T helper lymphocytes and effector memory T cytotoxic lymphocytes were observed. After skin re-infection, a rapid response of cytotoxic, helper, and memory T lymphocytes, memory B lymphocytes and plasmablasts, and macrophages was detected. In addition, a reduction i

SUBMITTER: Cakala-Jakimowicz M 

PROVIDER: S-EPMC9138836 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature