Nanoparticles Loaded with Docetaxel and Resveratrol as an Advanced Tool for Cancer Therapy.

ABSTRACT: A growing interest in the use of a combination of chemosensitizers and cytostatics for overcoming cancer resistance to treatment and the development of their delivery systems has been observed. Resveratrol (Res) presents antioxidant, anti-inflammatory and chemopreventive properties but also limits multidrug resistance against docetaxel (Dtx), which is one of the main causes of failure in cancer therapy with this drug. However, the use of both drugs presents challenges, including poor bioavailability, the unfavourable pharmacokinetics and chemical instability of Res and the poor water solubility and dose-limiting toxicity of Dtx. In order to overcome these difficulties, attempts have been made to create different forms of delivery for both agents. This review is focused on the latest develo

SUBMITTER: Jurczyk M 

PROVIDER: S-EPMC9138983 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature