The Role of the Metabolism of Zinc and Manganese Ions in Human Cancerogenesis.

ABSTRACT: Metal ion homeostasis is fundamental for life. Specifically, transition metals iron, manganese and zinc play a pivotal role in mitochondrial metabolism and energy generation, anti-oxidation defense, transcriptional regulation and the immune response. The misregulation of expression or mutations in ion carriers and the corresponding changes in Mn²⁺ and Zn²⁺ levels suggest that these ions play a pivotal role in cancer progression. Moreover, coordinated changes in Mn²⁺ and Zn²⁺ ion carriers have been detected, suggesting that particular mechanisms influenced by both ions might be required for the growth of cancer cells, metastasis and immune evasion. Here, we present a review of zinc and manganese pathophysiology suggesting that these ions might coo

SUBMITTER: Rozenberg JM 

PROVIDER: S-EPMC9139143 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature