Cutaneous Involvement in Diseases with Plasma Cell Differentiation: Diagnostic Approach.

ABSTRACT: Neoplasms with plasma cell differentiation may occasionally involve the skin. Cutaneous lesions may represent the first sign of an underlying systemic plasma cell malignancy, such as multiple myeloma, or the skin itself may be the primary site of occurrence of a hematological tumor with plasma cell differentiation. Starting from examples encountered in our daily practice, we discussed the diagnostic approach pathologists and clinicians should use when faced with cutaneous lesions with plasma cell differentiation. Cases of primary cutaneous marginal zone lymphoma, localized primary amyloidosis/amyloidoma, and cutaneous manifestations (secondary either to multiple myeloma or to plasmablastic lymphoma) are discussed, focusing on the importance of the adequate patient's work-up and precise cli

SUBMITTER: Zanelli M 

PROVIDER: S-EPMC9139249 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature