Analytical Validation of GFR_NMR: A Blood-Based Multiple Biomarker Assay for Accurate Estimation of Glomerular Filtration Rate.

ABSTRACT: Accurate and precise monitoring of kidney function is critical for a timely and reliable diagnosis of chronic kidney disease (CKD). The determination of kidney function usually involves the estimation of the glomerular filtration rate (eGFR). We recently reported the clinical performance of a new eGFR equation (GFR_NMR) based on the nuclear magnetic resonance (NMR) measurement of serum myo-inositol, valine, and creatinine, in addition to the immunoturbidometric quantification of serum cystatin C, age and sex. We now describe the analytical performance evaluation of GFR_NMR according to the Clinical and Laboratory Standards Institute guidelines. Within-laboratory coefficients of variation (CV%) of the GFR_NMR equation did not exceed 4.3%, with a maximum CV% for

SUBMITTER: Fuhrmann M 

PROVIDER: S-EPMC9139323 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature