Method for the Intraoperative Detection of IDH Mutation in Gliomas with Differential Mobility Spectrometry.

ABSTRACT: Isocitrate dehydrogenase (IDH) mutation status is an important factor for surgical decision-making: patients with IDH-mutated tumors are more likely to have a good long-term prognosis, and thus favor aggressive resection with more survival benefit to gain. Patients with IDH wild-type tumors have generally poorer prognosis and, therefore, conservative resection to avoid neurological deficit is favored. Current histopathological analysis with frozen sections is unable to identify IDH mutation status intraoperatively, and more advanced methods are therefore needed. We examined a novel method suitable for intraoperative IDH mutation identification that is based on the differential mobility spectrometry (DMS) analysis of the tumor. We prospectively obtained tumor samples from 22 patients, inclu

SUBMITTER: Haapala I 

PROVIDER: S-EPMC9139325 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature