Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway.

ABSTRACT: Social behavior is a basic domain affected by several neurodevelopmental disorders, including ASD and a heterogeneous set of neuropsychiatric disorders. The SCRIB gene that codes for the polarity protein SCRIBBLE has been identified as a risk gene for spina bifida, the most common type of neural tube defect, found at high frequencies in autistic patients, as well as other congenital anomalies. The deletions and mutations of the 8q24.3 region encompassing SCRIB are also associated with multisyndromic and rare disorders. Nonetheless, the potential link between SCRIB and relevant social phenotypes has not been fully investigated. Hence, we show that Scrib^crc/+ mice, carrying a mutated version of Scrib, displayed reduced social motivation behavior

SUBMITTER: Moreau MM 

PROVIDER: S-EPMC9139383 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature