The Genetic and Molecular Basis of Developmental Language Disorder: A Review.

ABSTRACT: Language disorders are highly heritable and are influenced by complex interactions between genetic and environmental factors. Despite more than twenty years of research, we still lack critical understanding of the biological underpinnings of language. This review provides an overview of the genetic landscape of developmental language disorders (DLD), with an emphasis on the importance of defining the specific features (the phenotype) of DLD to inform gene discovery. We review the specific phenotype of DLD in the genetic literature, and the influence of historic variation in diagnostic inclusion criteria on researchers' ability to compare and replicate genotype-phenotype studies. This review provides an overview of the recently identified gene pathways in populations with DLD and explores c

SUBMITTER: Mountford HS 

PROVIDER: S-EPMC9139417 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature