Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process.
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ABSTRACT:
SUBMITTER: Jahn K
PROVIDER: S-EPMC9139542 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process.
Jahn Kristin K Shumba Patience P Quach Phoenicia P Müsken Mathias M Wesche Jan J Greinacher Andreas A Rajagopal Lakshmi L Hammerschmidt Sven S Siemens Nikolai N
Cells 20220513 10
Group B streptococci (GBS) cause a range of invasive maternal-fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulation and thrombocytopenia. GBS express a hyper-hemolytic ornithine rhamnolipid pigment toxin with cytolytic and coagulatory activity. Here, we investigated the effects of GBS pigment on human platelets. ...[more]
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