Dataset Information

DiTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C₂-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation.

ABSTRACT: Hepatocellular carcinoma (HCC), the most common type of liver cancer, is the leading cause of cancer-related mortality worldwide. Chemotherapy is the major treatment modality for advanced or unresectable HCC; unfortunately, chemoresistance results in a poor prognosis for HCC patients. Exogenous ceramide, a sphingolipid, has been well documented to exert anticancer effects. However, recent reports suggest that sphingolipid metabolism in ceramide-resistant cancer cells favors the conversion of exogenous ceramides to prosurvival sphingolipids, conferring ceramide resistance to cancer cells. However, the mechanism underlying ceramide resistance remains unclear. We previously demonstrated that diTFPP, a novel phenoxyphenol compound, enhances the anti-HCC effect of C₂-ceramide. Here,

SUBMITTER: Chiu CC

PROVIDER: S-EPMC9139631 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Dataset Information

DiTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C₂-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation.

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Dataset Information

DiTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C2-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

DiTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C₂-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation.