Elevated Serotonin and NT-proBNP Levels Predict and Detect Carcinoid Heart Disease in a Large Validation Study.

ABSTRACT: Carcinoid heart disease (CHD) is a rare fibrotic cardiac complication of neuroendocrine tumors. Besides known biomarkers N-Terminal pro-B-type natriuretic peptide (NT-proBNP) and serotonin, activin A, connective tissue growth factor (CTGF), and soluble suppression of tumorigenicity 2 (sST2) have been suggested as potential biomarkers for CHD. Here, we validated the predictive/diagnostic value of these biomarkers in a case-control study of 114 patients between 1990 and 2021. Two time-points were analyzed: T₀: liver metastasis without CHD for all patients. T₁: confirmed CHD in cases (CHD+, n = 57); confirmed absence of CHD five or more years after liver metastasis in controls (CHD-, n = 57). Thirty-one (54%) and 25 (44%) females were included in CHD+ and CHD- patients,

SUBMITTER: Levy S 

PROVIDER: S-EPMC9139809 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature