Deciphering Innate Immune Cell-Tumor Microenvironment Crosstalk at a Single-Cell Level.

ABSTRACT: The tumor microenvironment encompasses various innate immune cells which regulate tumor progression. Exploiting innate immune cells is a new frontier of cancer immunotherapy. However, the classical surface markers for cell-type classification cannot always well-conclude the phenotype, which will further hinge our understanding. The innate immune cells include dendritic cells, monocytes/macrophages, natural killer cells, and innate lymphoid cells. They play important roles in tumor growth and survival, in some cases promoting cancer, in other cases negating cancer. The precise characterization of innate immune cells at the single-cell level will boost the potential of cancer immunotherapy. With the development of single-cell RNA sequencing technology, the transcriptome of each cell in the t

SUBMITTER: Sugimura R 

PROVIDER: S-EPMC9140036 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature