Quantitative Sodium (²³Na) MRI in Pediatric Gliomas: Initial Experience.

ABSTRACT:

Background

²³Na MRI correlates with tumor proliferation, and studies in pediatric patients are lacking.

The purpose of the study

(1) to compare total sodium concentration (TSC) between pediatric glioma and non-neoplastic brain tissue using ²³Na MRI; (2) compare tissue conspicuity of bound sodium concentration (BSC) using ²³Na MRI dual echo relative to TSC imaging.

Methods

TSC was measured in: (1) non-neoplastic brain tissues and (2) three types of manually segmented gliomas (diffuse intrinsic brainstem glioma (DIPG), recurrent supratentorial low-grade glioma (LGG), and high-grade glioma (HGG)). In a subset of patients, serial changes in both TSC and BSC (dual echo ²³Na MRI) were assessed.

Results

Twenty-six pediatric

SUBMITTER: Bhatia A 

PROVIDER: S-EPMC9140048 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature