Discovering sparse control strategies in neural activity.

ABSTRACT: Biological circuits such as neural or gene regulation networks use internal states to map sensory input to an adaptive repertoire of behavior. Characterizing this mapping is a major challenge for systems biology. Though experiments that probe internal states are developing rapidly, organismal complexity presents a fundamental obstacle given the many possible ways internal states could map to behavior. Using C. elegans as an example, we propose a protocol for systematic perturbation of neural states that limits experimental complexity and could eventually help characterize collective aspects of the neural-behavioral map. We consider experimentally motivated small perturbations-ones that are most likely to preserve natural dynamics and are closer to internal control mechanisms-to neural stat

SUBMITTER: Lee ED 

PROVIDER: S-EPMC9140285 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature