The role of prisons in disseminating tuberculosis in Brazil: A genomic epidemiology study.

ABSTRACT:

Background

Globally, prisons are high-incidence settings for tuberculosis. Yet the role of prisons as reservoirs of M. tuberculosis, propagating epidemics through spillover to surrounding communities, has been difficult to measure directly.

Methods

To quantify the role of prisons in driving wider community M. tuberculosis transmission, we conducted prospective genomic surveillance in Central West Brazil from 2014 to 2019. We whole genome sequenced 1152 M. tuberculosis isolates collected during active and passive surveillance inside and outside prisons and linked genomes to detailed incarceration histories. We applied multiple phylogenetic and genomic clustering approaches and inferred timed transmission trees.

Findings

M. tuberculosis seque

SUBMITTER: Walter KS 

PROVIDER: S-EPMC9140320 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature