Antidepressants and Vertebral and Hip Risk Fracture: An Updated Systematic Review and Meta-Analysis.

ABSTRACT: Although antidepressant drugs appear to play an active role in increasing fracture risk, their weight is still unclear. We conducted a PRISMA compliant systematic review and meta-analysis through PubMed/Scopus/Cochrane libraries and registered with PROSPERO (registration number CRD42021254006) to investigate the relationship between antidepressant drugs categories, including SSRIs, SNRIs, and TCAs, and the risk of hip and vertebral fractures. After screening 3122 items, we finally found 26 papers for qualitative analysis and 11 for quantitative synthesis. A total of 15,209,542 adult and elderly patients were identified, with a mean follow-up of 51 months and a major prevalence of women. We identified results largely for SSRIs, with only a small amount of data for SNRIs, TCAs, and NaSSA. No

SUBMITTER: de Filippis R 

PROVIDER: S-EPMC9140335 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature