Methylation Heterogeneity and Gene Expression of SPG20 in Solid Tumors.

ABSTRACT:

Introduction

The downregulation of the Spastic Paraplegia-20 (SPG20) gene is correlated with a rare autosomal recessive disorder called Troyer Syndrome. Only in recent years has SPG20 been studied and partially characterized in cancer. SPG20 has been shown to be hypermethylated in colorectal cancer, gastric cancer, non-Hodgkin's lymphoma and hepatocellular carcinoma. In this study, we analyze the methylation status and the gene expression of SPG20 in different tumors of various histological origins.

Methods

We analyzed the data generated through Infinium Human Methylation 450 BeadChip arrays and RNA-seq approaches extrapolated from The Cancer Genome Atlas (TCGA) database. The statistics were performed with R 4.0.4.

Results

We aimed to asses

SUBMITTER: Cusenza VY 

PROVIDER: S-EPMC9140344 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature