Tissue-Specific Variations in Transcription Factors Elucidate Complex Immune System Regulation.

ABSTRACT: Gene expression plays a key role in health and disease. Estimating the genetic components underlying gene expression can thus help understand disease etiology. Polygenic models termed "transcriptome imputation" are used to estimate the genetic component of gene expression, but these models typically consider only the cis regions of the gene. However, these cis-based models miss large variability in expression for multiple genes. Transcription factors (TFs) that regulate gene expression are natural candidates for looking for additional sources of the missing variability. We developed a hypothesis-driven approach to identify second-tier regulation by variability in TFs. Our approach tested two models representing possible mechanisms by which variations in TFs can affect gene ex

SUBMITTER: Lu H 

PROVIDER: S-EPMC9140347 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature